In Vivo Experimental Study on the Enhancement of Optical Clearing Effect by Laser Irradiation in Conjunction with a Chemical Penetration Enhancer

The penetration of optical clearing agents (OCAs) is restricted by the natural barrier function of the stratum corneum (SC) of the skin, which can be breached by physical and chemical methods to enhance the transcutaneous delivery of OCAs.To breach the barrier function of SC, we carried out the in vivo experimental study to enhance the optical clea

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A Combination of Blue Light at 460 nm and H2O2 for the Safe and Effective Eradication of Staphylococcus aureus in an Infected Mouse Skin Abrasion Model

Antibiotic-free approaches are more important than ever to address the rapidly growing problem of the antibiotic resistance crisis.The photolysis of the bacterial virulence factor staphyloxanthin using blue light at Games 460 nm (BL460 nm) has been found to effectively attenuate Staphylococcus aureus to chemical and physical agents.However, phototh

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Bispecific engineered antibody domains (nanoantibodies) that interact noncompetitively with an HIV-1 neutralizing epitope and FcRn.

Libraries based on an isolated human immunoglobulin G1 (IgG1) constant domain 2 (CH2) have been previously diversified by random mutagenesis.However, native isolated CH2 is not very stable and the generation of many mutations could lead to an increase in immunogenicity.Recently, we demonstrated that engineering an additional disulfide bond and remo

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